SORAFINA SORAFENIB TABLET IP 200MG

Product Description

Sorafina Sorafenib Tablet IP 200mg is a targeted therapy medication primarily used in the treatment of certain types of cancer. The active ingredient, Sorafenib, is a multi-kinase inhibitor that works by interfering with the growth and spread of cancer cells.

Key Details about Sorafina Sorafenib Tablet IP 200mg:

Active Ingredient:

• Sorafenib is the active ingredient, available in 200 mg tablet form.

Mechanism of Action:

Sorafenib targets specific proteins involved in cancer cell growth, tumor blood vessel formation (angiogenesis), and metastasis. It inhibits several kinases (enzymes) involved in the signaling pathways that control cancer cell proliferation and survival, as well as the formation of new blood vessels that tumors need to grow. Sorafenib targets RAF kinase, VEGFR, PDGFR, and other related proteins.

• RAF kinase inhibition prevents cancer cells from receiving growth signals.
• VEGFR (Vascular Endothelial Growth Factor Receptor) inhibition blocks the formation of blood vessels that tumors need for oxygen and nutrients.
• PDGFR (Platelet-Derived Growth Factor Receptor) inhibition also disrupts the growth of cancerous cells.

Indications (Uses):

Sorafenib is used to treat several types of advanced or metastatic cancer, including:

• Hepatocellular carcinoma (HCC): Liver cancer.
• Renal cell carcinoma (RCC): Kidney cancer.
• Differentiated thyroid carcinoma (DTC): In cases where the cancer is refractory to radioactive iodine treatment.
• Advanced melanoma: In combination with other treatments.
• Other cancers: It is also sometimes used in treating other cancers as part of clinical trials.

Dosage:

• Typical Adult Dose: The usual dosage of Sorafenib 200mg tablets is 400 mg twice daily, which is typically equivalent to 2 tablets of 200mg each, taken approximately 12 hours apart.
• Administration: The tablets should be taken orally with a full glass of water. They can be taken with or without food. It is important to follow your healthcare provider's instructions for dosing.
• Adjustments: The dose may be adjusted depending on the patient's tolerance to the medication or if side effects are observed.

Side Effects:

While Sorafenib can be effective in treating cancer, it can also cause side effects. Common side effects include:

• Skin-related issues:

  • Rash (often a papulopustular rash),
  • Dry or irritated skin,
  • Hand-foot syndrome (pain, redness, or peeling of the skin on hands and feet),
  • Pruritus (itching).

• Gastrointestinal problems:

  • Diarrhea,
  • Nausea and vomiting,
  • Loss of appetite.

• Fatigue and weakness are also commonly reported.

• Blood pressure changes: Hypertension (high blood pressure) or hypotension (low blood pressure) can occur.

• Liver enzyme abnormalities: Elevated liver enzymes may occur, indicating potential liver damage.

• Cardiovascular issues: Rarely, Sorafenib can cause heart problems, such as QT interval prolongation (a measure of heart rhythm), and can increase the risk of heart failure.

Serious Side Effects (Rare):

• Severe liver toxicity: Symptoms include yellowing of the skin or eyes (jaundice), severe abdominal pain, or unusual tiredness.
• Severe bleeding: Symptoms may include unexpected bleeding from the gums, nosebleeds, or in the stool (which could be black or tarry).
• Severe allergic reactions: Difficulty breathing, rash, swelling of the face or lips, and hives.

Precautions:

• Liver function: Since Sorafenib can cause liver toxicity, liver function should be monitored regularly during treatment. It may not be suitable for people with severe liver impairment.
• Blood pressure monitoring: Due to its potential effects on blood pressure, regular monitoring is important, especially if the patient has a history of hypertension or cardiovascular disease.
• Cardiac Monitoring: Those with existing heart problems should be monitored closely, as Sorafenib can affect heart rhythms.
• Pregnancy and breastfeeding: Sorafenib is not recommended during pregnancy, as it may harm the fetus. It should not be used during breastfeeding either, as it can pass into breast milk.
• Kidney function: Care should be taken in patients with kidney problems, as Sorafenib may affect renal function.

Drug Interactions:

Sorafenib can interact with several medications, including:

• Anticoagulants (e.g., warfarin): It may increase the risk of bleeding.
• CYP450 enzyme inhibitors/inducers: Sorafenib is metabolized by enzymes in the liver, so drugs that inhibit or induce these enzymes (e.g., rifampin, ketoconazole) can affect Sorafenib levels.
• Chemotherapy drugs: Sorafenib may interact with certain chemotherapy agents or other cancer treatments, so close monitoring is necessary.

Storage:

• Room temperature: Store the tablets in a cool, dry place (generally 20C to 25C or 68F to 77F).
• Out of reach of children: Keep the medication away from children and pets to prevent accidental ingestion.

Conclusion:

Sorafina Sorafenib 200mg Tablet IP is a targeted cancer therapy medication used to treat various types of advanced cancers, including liver, kidney, thyroid, and melanoma. By blocking specific proteins involved in cancer cell growth and blood vessel formation, it can slow down tumor progression. As with any cancer treatment, it requires careful monitoring for potential side effects, including liver toxicity, skin reactions, and blood pressure changes. Patients should work closely with their healthcare provider to adjust the dose and manage side effects.