Cavim Injection 125 mg

Product Description

Cavim 125 mg Injection contains Cefoperazone, a third-generation cephalosporin antibiotic. Cefoperazone is used to treat a variety of bacterial infections by inhibiting bacterial cell wall synthesis, leading to the destruction of the bacteria. It is often used in hospital settings for serious infections.

Indications

Cavim 125 mg Injection (Cefoperazone) is typically used to treat the following conditions:

1. Bacterial Infections:
   • Respiratory tract infections (e.g., pneumonia, bronchitis)
   • Urinary tract infections
   • Abdominal infections (e.g., peritonitis, intra-abdominal abscess)
   • Skin and soft tissue infections
   • Bone and joint infections
   • Bacteremia (blood infections) and sepsis
2. Infections caused by susceptible bacteria: Cefoperazone is active against a wide range of gram-positive and gram-negative bacteria, making it useful for infections caused by organisms like Streptococcus pneumoniae, Escherichia coli, and Pseudomonas aeruginosa.
3. Infections in immunocompromised patients: It can be used in patients with weakened immune systems, such as those undergoing chemotherapy or with chronic conditions that reduce immunity.

Mechanism of Action

Cefoperazone is a beta-lactam antibiotic that works by inhibiting the synthesis of the bacterial cell wall. It binds to penicillin-binding proteins (PBPs) on the bacterial cell membrane, preventing the final stages of peptidoglycan synthesis and causing the bacterial cell wall to weaken, leading to bacterial cell lysis (destruction). The broad-spectrum action of Cefoperazone makes it effective against both gram-positive and gram-negative bacteria.

Dosage and Administration

The dosage of Cavim 125 mg Injection (Cefoperazone) depends on the severity of the infection and the patient's condition. It is typically administered intravenously (IV) or intramuscularly (IM).

• Typical Dosage:

  • For Adults:
    • The usual dose is 1“2 grams every 12 hours, depending on the severity and type of infection.
    • Severe infections may require doses up to 2 grams every 12 hours.
  • For Pediatric Patients:
    • The dose is usually based on the child™s weight, typically ranging from 50“100 mg/kg/day, divided into 2“3 doses.

• Administration:

  • Intravenous (IV) administration: Cefoperazone can be given through a slow intravenous injection or as an IV infusion.
  • Intramuscular (IM) administration: The injection is given directly into the muscle, but this route is less commonly used in severe infections.

Side Effects

Common side effects of Cavim 125 mg Injection (Cefoperazone) may include:

• Gastrointestinal Issues:
  • Nausea, vomiting, diarrhea, or abdominal pain.
  • A change in bowel movements.
• Injection Site Reactions: Pain, redness, or swelling at the injection site.
• Allergic Reactions: Rash, itching, or swelling, particularly around the face and throat. More serious reactions include anaphylaxis, a severe allergic reaction that requires immediate medical attention.

Serious side effects (although rare) may include:

• Severe Allergic Reactions: Anaphylaxis (difficulty breathing, swelling of the face and throat, and hives).
• Hematologic Issues: Low white blood cell count (leukopenia), low platelet count (thrombocytopenia), or anemia.
• Liver Dysfunction: Elevated liver enzymes, jaundice (yellowing of the skin or eyes).
• Kidney Dysfunction: Rare, but possible damage to kidneys, which may require dose adjustments.
• Clostridium difficile-associated diarrhea: This is a risk with many antibiotics and can lead to severe diarrhea or colitis.

Precautions and Warnings

• Allergic Reactions: If you have a history of allergic reactions to penicillin or other beta-lactam antibiotics, you should inform your doctor, as there may be a risk of a cross-reaction.

• Renal Impairment: Cefoperazone is excreted primarily through the kidneys, so in patients with renal impairment, dose adjustments may be necessary.

• Hepatic Impairment: Patients with liver problems should be closely monitored while on Cavim, as liver enzyme elevations can occur.

• Pregnancy and Breastfeeding:

  • Pregnancy: Cefoperazone is classified as Category B for pregnancy (no proven risk to the fetus), but should only be used if the benefits outweigh the risks.
  • Breastfeeding: Cefoperazone can be excreted in breast milk, but it is generally considered safe for short-term use. However, the potential risk to the baby should be considered.

• Superinfection: Long-term use of antibiotics, including Cefoperazone, may result in a secondary infection due to the overgrowth of non-susceptible organisms, such as fungi.

Important Considerations

• Adherence to Prescribed Dosing: Ensure that you follow the healthcare provider's instructions carefully, and do not stop the treatment early, even if you start feeling better. This helps to prevent antibiotic resistance and ensures the infection is fully treated.
• Monitoring During Treatment: While on Cavim 125 mg, liver function, renal function, and complete blood counts may need to be monitored, especially for long-term use.

Conclusion

Cavim 125 mg Injection (Cefoperazone) is a broad-spectrum antibiotic used to treat serious bacterial infections. It is effective against a wide range of pathogens and is commonly used in hospital settings. However, it can cause side effects such as gastrointestinal issues, allergic reactions, and, in rare cases, liver or kidney dysfunction. Regular monitoring and proper administration are crucial to ensure the effectiveness of the treatment and avoid complications.