Imat 400 Mg Tablets Imatinib 400 Mg

About Imat 400 Mg Tablets Imatinib 400 Mg

Imat 400 mg Tablets contain Imatinib, a targeted therapy medication used primarily in the treatment of certain cancers and hematological (blood) disorders. Imatinib is a tyrosine kinase inhibitor (TKI), which works by blocking specific enzymes (tyrosine kinases) that are involved in the growth of cancer cells. It is particularly effective against cancers that have genetic mutations causing abnormal tyrosine kinase activity.

Indications

Imatinib is primarily used for the treatment of:

• Chronic myelogenous leukemia (CML): A type of leukemia where cancerous white blood cells multiply abnormally.
• Gastrointestinal stromal tumors (GISTs): A type of tumor that occurs in the digestive tract, often in the stomach or small intestine.
• Acute lymphoblastic leukemia (ALL): A cancer of the blood and bone marrow, particularly in cases where the cancer cells have the Philadelphia chromosome (an abnormal chromosome associated with leukemia).
• Myelodysplastic/Myeloproliferative Diseases: Imatinib may also be used for some other blood cancers and bone marrow conditions, like chronic eosinophilic leukemia.
• Systemic mastocytosis: A rare condition where an excess of mast cells accumulates in various parts of the body.

Mechanism of Action

Imatinib works by inhibiting the activity of specific tyrosine kinases, including BCR-ABL, which is produced by the Philadelphia chromosome abnormality in CML. By blocking these tyrosine kinases, Imatinib interferes with the signaling that promotes cancer cell growth and survival, ultimately slowing or halting the progression of cancer.

Dosage and Administration

• Typical Dosage:

  • For CML, the usual starting dose is 400 mg once daily. The dose may be adjusted based on the patients response and any side effects.
  • For GISTs, the typical dose is also 400 mg once daily, though higher doses may be prescribed.
  • For ALL, the usual dose is 400 mg once daily as well.

  Imatinib tablets should be taken with food and a full glass of water to minimize gastrointestinal irritation.

• Dose Adjustments: The dose may be adjusted depending on how well the patient responds to the treatment, or if side effects occur.

Side Effects

Common side effects include:

• Nausea and vomiting
• Fatigue
• Edema (swelling), particularly around the eyes or in the lower legs
• Muscle cramps or joint pain
• Rash
• Diarrhea

Serious side effects can include:

• Heart issues: Imatinib can cause or worsen heart problems, especially in patients with pre-existing heart disease.
• Liver toxicity: Monitoring of liver function is required, as Imatinib can cause elevated liver enzymes.
• Bone marrow suppression: Can lead to low blood counts, including neutropenia (low white blood cells), anemia (low red blood cells), and thrombocytopenia (low platelets), increasing the risk of infections, bleeding, and fatigue.
• Fluid retention: Leading to swelling in the body, which can be severe in some cases.

Precautions and Warnings

• Drug Interactions: Imatinib can interact with several other medications, including certain antifungals, antibiotics, and heart medications. It is important to inform your healthcare provider about all the medications you are taking.
• Liver Function: Liver function tests should be performed regularly to monitor for potential liver toxicity.
• Heart Issues: Imatinib should be used cautiously in patients with heart problems or fluid retention, as it can cause or worsen these conditions.
• Pregnancy and Breastfeeding: Imatinib should generally be avoided during pregnancy unless the benefits outweigh the risks, as it can cause harm to the fetus. It is also not recommended for use while breastfeeding.
• Infection: Patients should be monitored for signs of infections since the drug can reduce white blood cell counts.

Important Considerations

• Monitoring: Regular blood tests, including liver and kidney function tests, as well as monitoring blood cell counts, are required during treatment with Imatinib.
• Long-term use: Imatinib is usually taken as a long-term treatment, and its important to continue regular follow-ups to ensure effectiveness and minimize side effects.

Conclusion

Imatinib is an effective medication for managing certain cancers, particularly those involving abnormal tyrosine kinases like CML and GISTs. It is important to follow your doctors instructions for dosing and to attend regular check-ups to manage any potential side effects.

Effective Cancer Therapy

IMAT 400 Mg Tablets are designed to effectively manage specific cancers such as CML, ALL, and GIST by inhibiting abnormal cell proliferation. The active ingredient, Imatinib Mesylate, targets tyrosine kinases which are enzymes involved in cancer cell growth. This innovative approach helps in slowing disease progression and improving patient outcomes under medical supervision.


Quality Assurance and Safety

Manufactured by Intas Pharmaceuticals Ltd. under strict WHO GMP and ISO certified standards, IMAT 400 Mg Tablets ensure high pharmaceutical quality. Each batch carries identification and expiry details for traceability and patient safety. Tablets are supplied in sealed packs and require a prescription, making them suitable only for patients deemed eligible by a physician.


Proper Storage and Handling

To protect the efficacy of IMAT 400 Mg Tablets, it is important to store them below 30C, away from moisture and direct light. Unused or expired medication should be discarded according to local regulations. Always keep the tablets in their original packaging until use and out of reach of children.