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Cresp 25 Mg Injection

Cresp 25 Mg Injection

1450 INR/Pack

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Cresp 25 Mg Injection Price And Quantity

  • 100 Pack
  • 1450 INR/Pack

Cresp 25 Mg Injection Trade Information

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  • 3 Days
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Product Description

Cresp 25 mg Injection contains Darbepoetin alfa, which is a synthetic version of erythropoietin. Erythropoietin is a hormone that stimulates the production of red blood cells in the bone marrow. Darbepoetin alfa has a longer half-life than the natural form, allowing it to be administered less frequently. It is used primarily in the treatment of anemia, particularly in patients with chronic kidney disease (CKD) or those undergoing chemotherapy.

Indications

Cresp 25 mg Injection is used for the following conditions:

  1. Anemia due to Chronic Kidney Disease (CKD): It is used to treat anemia in patients with chronic kidney disease, especially those who are undergoing dialysis or those not on dialysis.
  2. Anemia due to Chemotherapy: It is used in cancer patients undergoing chemotherapy, particularly those with non-myeloid cancers, to reduce the need for blood transfusions.
  3. Anemia due to HIV: In some cases, it may also be used to treat anemia associated with HIV treatment, particularly in patients receiving certain antiretroviral medications.

Mechanism of Action

Darbepoetin alfa is a modified form of erythropoietin. It stimulates the erythropoietin receptors on erythroid progenitor cells in the bone marrow, promoting the production of red blood cells. The medication mimics the action of the naturally occurring erythropoietin hormone, helping to maintain normal red blood cell levels, particularly in conditions where anemia is present.

The longer half-life of Darbepoetin alfa allows for less frequent dosing, which is a significant advantage over the regular erythropoietin preparations.

Dosage and Administration

  • Typical Dosage:
    • For Chronic Kidney Disease (CKD):
      • The initial dose is typically 0.45 mcg/kg body weight administered once a week.
      • Depending on the response, the dose may be adjusted, and the frequency of administration can be reduced to once every two weeks or even once a month.
    • For Chemotherapy-Induced Anemia:
      • The usual starting dose is 2.25 mcg/kg body weight administered once a week.
      • As with CKD, the dose may be adjusted based on the hemoglobin levels and patient response.
  • Administration:
    • Subcutaneous or Intravenous Injection: Cresp is typically administered subcutaneously (under the skin) or, in the case of dialysis patients, intravenously (directly into the vein).
    • Injection Sites: For subcutaneous administration, common injection sites include the thigh, abdomen, or upper arm.
    • The injection should be done by a healthcare provider in a clinical setting or, in some cases, under the guidance of a healthcare professional for home use.

Side Effects

Common side effects of Cresp 25 mg include:

  • Hypertension (High Blood Pressure): This is a common side effect, especially in patients with chronic kidney disease.
  • Fatigue or tiredness
  • Joint pain or muscle aches
  • Headache
  • Swelling in the legs, arms, or face

Serious side effects (though less common) may include:

  • Thromboembolic Events: Increased risk of blood clots, such as deep vein thrombosis (DVT), pulmonary embolism (PE), or stroke. Blood clots can be serious, so monitoring is required.
  • Heart Issues: There may be an increased risk of heart attack, stroke, or heart failure in certain high-risk patients, especially if hemoglobin levels rise too quickly.
  • Severe Allergic Reactions: Though rare, anaphylaxis (a severe allergic reaction) can occur, with symptoms such as rash, itching, shortness of breath, or swelling of the throat and face.

Precautions and Warnings

  • Blood Pressure Monitoring: As Cresp 25 mg can increase blood pressure, it is important to regularly monitor blood pressure during treatment. Adjustments to antihypertensive therapy may be necessary.
  • Hemoglobin Levels: Treatment should be carefully monitored to ensure that hemoglobin does not rise too rapidly or too high, as this increases the risk of thromboembolic events. The goal is usually to maintain hemoglobin levels between 10-12 g/dL in most patients.
  • Iron Deficiency: For Darbepoetin alfa to work effectively, adequate iron stores must be present in the body. Patients may require iron supplements along with this medication, as iron is essential for red blood cell production.
  • Thromboembolic Risk: Darbepoetin alfa has been associated with an increased risk of blood clots, especially in patients who are prone to cardiovascular or cerebrovascular events. Clots may also form if the hemoglobin levels increase too quickly.
  • Pregnancy: Cresp 25 mg is not recommended during pregnancy unless absolutely necessary. It is classified as Category C, meaning its safety during pregnancy has not been well established. The medication may be used if the benefits outweigh the risks.
  • Breastfeeding: It is not known whether Darbepoetin alfa is excreted in breast milk, so caution is advised when using this medication in breastfeeding women.

Important Considerations

  • Adherence to Dosage: Adherence to the prescribed dosing schedule is critical for the treatment to be effective. Skipping doses or altering the frequency may result in worsening anemia or other complications.
  • Injection Technique: If the injection is administered at home, ensure that you are properly trained in the injection technique and follow the guidance of your healthcare provider.
  • Regular Blood Tests: Regular monitoring of hemoglobin levels, blood pressure, and iron status is required to ensure the safety and effectiveness of the treatment.

Conclusion

Cresp 25 mg Injection (Darbepoetin alfa) is a synthetic erythropoiesis-stimulating agent used to treat anemia in patients with chronic kidney disease, those undergoing chemotherapy, or those with HIV-related anemia. By stimulating the production of red blood cells, it helps to alleviate symptoms of anemia and reduce the need for blood transfusions. However, it requires careful monitoring to avoid complications such as high blood pressure, blood clots, and heart issues.

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