Omeprazole & Domperidone Capsules 20/10mg

Product Description

Omeprazole & Domperidone Capsules 20mg/10mg is a combination medication that contains Omeprazole (a proton pump inhibitor) and Domperidone (a prokinetic agent). This combination is commonly used to manage conditions related to gastroesophageal reflux disease (GERD), gastric ulcers, acid reflux, and other digestive disorders.

Key Components and Their Functions:

1. Omeprazole (20mg):

   • Omeprazole is a proton pump inhibitor (PPI) that works by reducing the amount of acid produced in the stomach. It blocks the proton pump, an enzyme system in the stomach lining that produces gastric acid.
   • It is used to treat conditions like GERD, stomach ulcers, and duodenal ulcers, and to prevent ulcers caused by NSAIDs (non-steroidal anti-inflammatory drugs).
   • Omeprazole helps relieve symptoms like heartburn, acid regurgitation, and stomach discomfort caused by excessive stomach acid.

2. Domperidone (10mg):

   • Domperidone is a prokinetic agent that helps to improve the motility of the stomach and intestines. It works by blocking dopamine receptors in the gastrointestinal tract, leading to improved movement of food through the digestive system and reducing symptoms of nausea and vomiting.
   • Domperidone is particularly helpful in conditions where delayed gastric emptying (gastroparesis) or reflux occurs, which can contribute to symptoms like bloating, nausea, and regurgitation.

Key Uses:

• Gastroesophageal Reflux Disease (GERD):

  • Omeprazole reduces stomach acid, while Domperidone helps reduce the sensation of acid reflux and promotes the emptying of the stomach. This combination helps relieve symptoms like heartburn and regurgitation in GERD.

• Gastric Ulcers & Duodenal Ulcers:

  • Omeprazole promotes healing of gastric and duodenal ulcers by reducing stomach acid, allowing the ulcerated tissue to heal more effectively.

• Dyspepsia (Indigestion):

  • This combination can be used to treat indigestion or discomfort caused by acid reflux and delayed gastric emptying.

• Nausea and Vomiting:

  • Domperidone helps relieve symptoms of nausea and vomiting, especially if the nausea is associated with acid reflux or delayed gastric emptying.

• Gastroparesis (Delayed Stomach Emptying):

  • Domperidone is effective in helping the stomach empty more efficiently, which can help manage symptoms of gastroparesis in patients with diabetes or other conditions that slow stomach motility.

How It Works:

• Omeprazole reduces the production of stomach acid by inhibiting the proton pump in the stomach lining, lowering acid secretion.
• Domperidone promotes gastrointestinal motility and helps the stomach empty more quickly, which reduces symptoms like nausea, bloating, and regurgitation associated with reflux or delayed gastric emptying.

Dosage:

• The typical dose for Omeprazole & Domperidone Capsules 20mg/10mg is usually one capsule per day, but your doctor may adjust the dosage based on your condition and severity of symptoms.
• It is important to follow your doctor's specific dosage instructions. This medication is often prescribed for a short duration of treatment (typically 4 to 8 weeks), but the length of treatment may vary.

How to Take:

• Take the capsule whole, with a glass of water.
• Do not crush or chew the capsule, as it is designed to release the medication slowly in the stomach.
• It is generally recommended to take Omeprazole & Domperidone Capsules before a meal, typically in the morning before breakfast.

Precautions:

• Liver Problems: If you have liver disease, your doctor may adjust the dosage or monitor liver function during treatment.
• Kidney Problems: People with kidney problems may also need to have their dosage adjusted.
• Pregnancy and Breastfeeding: The safety of Omeprazole during pregnancy is generally considered acceptable, but Domperidone should be used with caution during pregnancy, and it is not recommended during breastfeeding. Always consult your healthcare provider if you are pregnant or breastfeeding.
• Long-Term Use: Long-term use of Omeprazole can lead to low levels of magnesium, calcium, and vitamin B12. Your doctor may monitor your levels if you're on long-term therapy.

Side Effects:

• Common Side Effects:
  • Headache
  • Diarrhea
  • Stomach pain or discomfort
  • Nausea or vomiting
  • Dizziness
• Serious Side Effects:
  • Severe allergic reactions: Rash, swelling of the face, lips, or throat, trouble breathing
  • Heart-related issues (from Domperidone): Fast or irregular heartbeat, chest pain, dizziness, or fainting
  • Severe stomach pain or persistent diarrhea (which may indicate a Clostridium difficile infection)
  • Muscle cramps, weakness, or fatigue (which may indicate low magnesium levels from long-term Omeprazole use)

Drug Interactions:

• Omeprazole may interact with certain medications, including:

  • Warfarin (blood thinner): Omeprazole can increase the effect of warfarin, increasing the risk of bleeding.
  • Clopidogrel (blood thinner): Omeprazole can reduce the effectiveness of clopidogrel.
  • Certain antifungal medications, such as ketoconazole and itraconazole, may have altered absorption when taken with Omeprazole.
  • Methotrexate: High doses of methotrexate can interact with Omeprazole and may require dose adjustments.

• Domperidone interacts with medications that affect the heart's rhythm, such as antiarrhythmic drugs (e.g., amiodarone), or drugs that affect the QT interval, which can lead to serious heart issues.

• Antacids or other medications that affect stomach acid may interact with Omeprazole, so it™s essential to inform your healthcare provider of all medications you're taking.

Storage:

• Store the capsules at room temperature, away from moisture and heat.
• Keep the capsules in their original container and ensure the lid is tightly closed to protect the medication from moisture.

Conclusion:

Omeprazole & Domperidone Capsules 20mg/10mg is a combination medication used to treat a variety of digestive issues, including GERD, gastric ulcers, indigestion, nausea, and vomiting. Omeprazole helps reduce stomach acid, while Domperidone promotes better stomach motility. It is important to follow the prescribed dosage and duration of treatment. If you experience any serious side effects or symptoms, contact your healthcare provider immediately. As with all medications, be sure to inform your doctor of any other medications you are taking to avoid potential interactions.